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A pool of mutated Tet repressors is created as in Example 61 and cloned into an expression vector comprising a promoter active in Staphylococcus aureus, minocycline 50 mg capsule for acne such as the xyl-operon promoter of Bacillus, expression may be regulated by particular carbon source (xyl/mal). It appears clear, minocycline dosage for schizophrenia therefore, that this agent should be used in combination with at least one other effective agent, preferably an aminoglycoside if the organisms do not exhibit high-level aminoglycoside resistance!